H.S. Hussain, Faiq and K A. Khudhur, Hussein (2018) Synthesis and Characterization of Some New Symmetrical Bis-Isatins Derived From p-Substituted Aromatic Amines. Eurasian Journal of Science and Engineering, 4 (1). pp. 56-69. ISSN 24145629
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Abstract
A series of p-substituted isonitrosoacetanilide 2(a-g) were prepared via the condensation of psubstitutedaromatic amines (benzene-1,4-diamine,o-tolidine,4,4’-diaminodiphenylmethane, p bromoaniline p-nitroaniline, p-aminobenzoic acid and p-toluidine) with chloral hydrate and hydroxylamine hydrochloride in aqueous solution of sodium sulfate and absolute ethanol as a co-solvent under reflux conditions. The compounds 2(a-g) were cyclized in the presence of a strong acid to obtain 5-sudstituted isatin 3(a-f), which were condensed with aromatic diamines to some new bis-azomethine of isatin 4(a-h) in the presences of catalytic amounts of glacial acetic acid in EtOH. On the other hand some new bis Azomethine of isatin 5(a-d) were synthesized, from the reaction of di-isatins with aromatic monoamines (pyridin-2-amine and 5-chloropyridin-2-amine) in the presences of catalytic amounts of glacial acetic acid in DMSO. The new synthesized compounds were identified using spectroscopic techniques (IR, 1H-NMR, 13C-NMR, DEPT-135, Elemental analysis and Mass Spectroscopy). Finally the prepared compounds have been screened for antimicrobial activity in vitro against two types of bacteria Staphylococcus-aureus (Gr+ve) and Escherichia-coli (Gr-ve) the results showed that most of the prepared compounds are sensitive against both types of tested bacteria
Item Type: | Article |
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Uncontrolled Keywords: | Bis-Isonitrosoacetanilide , 5-Substituted Isatin , Bis-Isatins, Bis-Azomethine |
Subjects: | R Medicine > R Medicine (General) |
Divisions: | Eurasian Journal of Science and Engineering > VOL 4, NO 1 (2018) |
Depositing User: | ePrints deposit |
Date Deposited: | 12 Sep 2020 20:54 |
Last Modified: | 23 Feb 2021 07:48 |
URI: | http://eprints.tiu.edu.iq/id/eprint/179 |
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