Strategies to overcome the main challenges of the use of exosomes as drug carrier for cancer therapy

Mahmud Hussen, Bashdar and Sedeeq Hama Faraj, Goran and Fatih Rasul, Mohammad and Jamal Hidayat, Hazha and Salihi, Abbas and Baniahmad, Aria and Taheri, Mohammad and Ghafouri‑Frad, Soudeh (2022) Strategies to overcome the main challenges of the use of exosomes as drug carrier for cancer therapy. Cancer Cell International, 22.

Text (Research Article) s12935-022-02743-3.pdf - Published Version Download (3MB)

Abstract

Exosomes are naturally occurring nanosized particles that aid intercellular communication by transmitting biological information between cells. Exosomes have therapeutic efficacy that can transfer their contents between cells as natural carriers. In addition, the exosomal contents delivered to the recipient pathological cells significantly inhibit cancer progression. However, exosome-based tumor treatments are inadequately precise or successful, and various challenges should be adequately overcome. Here, we discuss the significant challenges that exosomes face as drug carriers used for therapeutic targets and strategies for overcoming these challenges in order to promote this new incoming drug carrier further and improve future clinical outcomes. We also present techniques for overcoming these challenges.

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