An Overview Of Current Developments In The Synthesis Of Carbon Nanotubes And Their Use In Medicinal Applications

Porwal, Omji (2022) An Overview Of Current Developments In The Synthesis Of Carbon Nanotubes And Their Use In Medicinal Applications. Journal of Pharmaceutical Negative Results, 13 (8). pp. 3691-3705.

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Abstract

In order to address problems associated with conventional drug therapy, such as limited drug solubility, poor biodistribution, lack of property, and unfavourable pharmacological medicine, new nanomaterials have been extensively investigated in recent years for drug delivery applications. Among them, carbon nanotubes (CNTs) are well known and rank among the most notable innovations in the field of nanotechnology because to their unique chemical science design, characteristics, and potential for usage in a variety of industries. CNTs are acknowledged as nano-architecture carbon allotropes with length-to-diameter ratios up to 1,000,000. CNTs frequently have single, double, or multiple walls and are square sheets of rolled graphene with SP2 coupling.The key characteristics of CNTs include their light weight, small size with a high aspect ratio, distinctive surface area, resilience, sensible tensile strength, and sensible conducting properties, which make them useful as fillers in a variety of materials including polymers, metallic surfaces, and ceramics. These cylindrical carbon molecules' potential uses in nanomedicine, nanotechnology, energy, textiles, actuators, sensors, composite materials, membranes, and capacitors have generated a great deal of enthusiasm in the pharmacy community. CNTs are refunctionalized or altered to hold payloads or interact with biological molecules since they are chemically inert and soluble in neither water nor other organic solvents. Due to their widespread use in medical applications such as the delivery of drugs, genes, and DNA as well as for biosensing, CNTs are best functionalized with proteins. They have the ability to cross membranes, transporting medicinal drugs, vaccinations, and nucleic acids deep inside the cell to previously unreachable locations. Numerous processes, such as flame synthesis, sol gel, silane solution, arc discharge, laser ablation, and chemical vapour deposition, have been devised to create nanotubes in significant numbers. The majority of the procedures used to purify CNTs include oxidation, acid treatment, annealing, sonication, chemical filtering, and functionalization techniques. High-purity purification methods must to be developed, though. These structures' striking advantages include their electrical, mechanical, optical, and chemical properties, which pave the way for potential future applications. This in-depth study focused on the synthesis, purification, functionalization, characteristics, advantages, applications, and most recent developments related to the use of CNTs for drug administration. The toxic effect of CNTs was also imparted in an extremely condensed form.

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