Antimicrobial Activity Of New Synthetic Derivative Of Sesamol And Sesamum Indicum Seeds Extract Against Meningitis Causing Bacteria

Manogaran, Yoghinni and Porwal, Omji and Shanmugavelu, Shalini and Jagadeesan, Dharshini and Kumar Singh, Sachin and Gupta, Saurabh and Kumar Patel, Dinesh and Singh, Amit and Chitranshi, Nitin (2022) Antimicrobial Activity Of New Synthetic Derivative Of Sesamol And Sesamum Indicum Seeds Extract Against Meningitis Causing Bacteria. Journal of Pharmaceutical Negative Results, 13 (4). pp. 2241-2249.

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Abstract

The facts over S. aureus and E. coli to cause meningitis, and the antimicrobial potential of Sesame seeds and Sesamol were motivation for present study to compare the antibacterial potential of new synthetic derivativeof Sesamol (SDS) and Sesamum indicum seeds extract against meningitis causing bacteria (MCB). Present study involved synthesis of SDS and preparation of sesame seeds extract. The SDS was characterized using ATR-IR, 1H-NMR and Mass spectrometric data. Both SDS and sesame extract were tested for the inhibitory potential against MCB, namely: S. aureus and E. coli. Among both, the SDS exhibited higher inhibitory potential when compared with sesame extract. Based on the results present study concludes that SDS possess high inhibition potential against MCB and recommends that SDSmust be further evaluated for its clinical significance.

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