Regulatory NK cells in autoimmune disease

Bahadorian, Davood and Mollazadeh, Samaneh and Mirazi, Hosein and Abdulsattar Faraj, Tola and Kheder, Ramiar and Esmaeili, Seyed-Alireza (2023) Regulatory NK cells in autoimmune disease. Iranian Journal of Basic Medical Sciences, 26. pp. 609-616.

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NK cells are defined as the major components of the immunological network which exerts defense against tumors and viral infections as well as regulation of innate and adaptive immunity, shaped through interaction with other cells like T cells. According to the surface markers, NK cells can be divided into CD56dim NK and CD56bright NK subsets. CD56bright NK cells usually are known as regulatory NK cells. Once the immune system loses its self-tolerance, autoimmune diseases develop. NK cells and their subsets can be altered during autoimmune diseases, indicative of their prominent regulatory roles and even pathological and protective functions in autoimmune disorders. In this regard, activation of CD56bright NK cells can suppress activated autologous CD4+ T cells and subsequently prevent the initiation of autoimmunity. In this review article, we summarize the roles of regulatory NK cells in autoimmune disease occurrence which needs more research to uncover their exact related mechanism. It seems that targeting NK cells can be a promising therapeutic platform against autoimmune diseases.

Item Type: Article
Uncontrolled Keywords: Autoimmune disease CD56bright NK cell Cytokine Immunology Regulatory NK cell
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RD Surgery
R Medicine > RT Nursing
Depositing User: ePrints deposit
Date Deposited: 18 Sep 2023 13:29
Last Modified: 18 Sep 2023 13:29

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