Co-enzyme Q-10 and its Effect on Periodontal Disease and Oral Cancer: A Systematic Review Article

Dawood Salman, Faraed and Jabbar Hussein, Aya and Hussein Kamel, Jabbar (2023) Co-enzyme Q-10 and its Effect on Periodontal Disease and Oral Cancer: A Systematic Review Article. ACTA SCIENTIFIC MEDICAL SCIENCES, 7 (3). pp. 92-103. ISSN 2582-0931

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Abstract

Background: To combat the excess production of free radicals in periodontal disease, antioxidant medications are employed. Free radicals (FRs) and reactive oxygen species (ROS) are the major contaminants that Co-Q10 primarily effectively removes in order to perform its intercellular antioxidant function, this study is aimed to: 1. Analyze the results of using perio Q gel (coenzyme Q10) intravenously only. 2. As an additional step in the treatment of patients with chronic periodontitis in conjunction to scaling and root planning on the periodontal clinical criteria. 3. Examine which of the various treatment modalities improved clinical periodontal markers more at 3 and 6 weeks. Materials and Methods: Clinical periodontal markers like the Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Relative Attachment Level (RAL) were evaluated at the first visit, 3 weeks, and 6 weeks. Results: When compared to the SRP group, the clinical parameters PPD and RAL of the combination group significantly decreased, according to intergroup analysis. In all groups, the reduction in PI, GI, BOP, PPD, and RAL across the three visits was highly significant when intra-group analysis was performed. Conclusion: By using the gel in addition to scaling and root planning rather than only scaling and root planning alone, the clinical periodontal parameters improved more significantly. The ability to employ the gel as the only substance to support common periodontitis treatment methods. In the periodontal treatment phase, the clinical metrics considerably improved, showing that CoQ10 expands treatment possibilities by enhancing the host response to disease activity. All living things possess the lipid-soluble endogenous antioxidant coenzyme Q10. Coenzyme Q10 may be a therapy for periodontitis, according to the pharmacology of the substance. To establish its precise function in the treatment of periodontitis, including both as an adjuvant and a primary therapeutic agent, as well as the right dosage, efficacy, and bioavailability, more research is required.

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