CHEMICAL BIOLOGY OF NATURAL PRODUCTS EXPANDING THE DRUG DISCOVERY TOOLBOX WITH BIOACTIVE MOLECULES

Kumar Padarthi, Pavan and Kumar Agarwal, Manuj and Sanjeeb Kumar Patro, B and Manoj Bhadane, Suvarna and Javed Naquvi, Kamran and Chandra Panda, Krishna and K J, Mangala and Ginjupalli, Murali (2024) CHEMICAL BIOLOGY OF NATURAL PRODUCTS EXPANDING THE DRUG DISCOVERY TOOLBOX WITH BIOACTIVE MOLECULES. African Journal of Biological Sciences, 6 (9). pp. 1145-1170. ISSN 2663-2187

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Abstract

Natural products have long served as a rich source of bioactive compounds with diverse chemical structures and pharmacological activities, making them invaluable resources in drug discovery and development. This review explores the intricate landscape of natural product-based drug discovery, highlighting its challenges, opportunities, and implications in expanding the pharmaceutical toolbox. We delve into the structural complexity and chemical diversity of natural products, examining their role in target identification, validation, and drug lead discovery. Through interdisciplinary collaboration and innovative methodologies, researchers can overcome hurdles in synthesis, characterization, and optimization to harness the full potential of natural products as therapeutic agents. Moreover, the development of synthetic analogs inspired by natural products offers avenues for innovation and optimization in drug discovery, promising enhanced pharmacological properties and efficacy. The implications of natural product research extend beyond drug discovery, offering opportunities for drug repurposing, combination therapies, and personalized medicine approaches. By integrating natural product research with cutting-edge technologies, such as genomics, metabolomics, and artificial intelligence, researchers can accelerate the pace of drug discovery and translation, bringing new medicines to patients more efficiently. In conclusion, the potential impact of natural products in pharmaceutical development is profound, offering a beacon of hope and inspiration for addressing the unmet medical needs of our time and shaping the course of medical history for generations to come.

Item Type: Article
Uncontrolled Keywords: Chemical biology, natural products, drug discovery, bioactive molecules, toolbox expansion
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Depositing User: ePrints deposit
Date Deposited: 27 Aug 2024 13:44
Last Modified: 27 Aug 2024 13:44
URI: http://eprints.tiu.edu.iq/id/eprint/1516

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