Polycyclic aromatic hydrocarbon exposure during pregnancy and changes in umbilical renal function

Hsu, Chou-Yi and Liu, Cong and S. Morozova, Natalia and Althaf Hussain, Shaik and Kumar, Ashwani and Sani Mohammed, Jaafaru and Pramanik, Atreyi and Juraev, Nizomiddin and Hayif Jasim Ali, Saad and Lari Najafi, Moslem (2024) Polycyclic aromatic hydrocarbon exposure during pregnancy and changes in umbilical renal function. Environmental Sciences Europe, 36 (90). ISSN 2190-4715

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Abstract

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with significant adverse effects on human health, particularly concerning fetal development during pregnancy. This study investigates the relationship between maternal exposure to particulate matter-bound (PM-bound) PAHs and potential alterations in fetal renal function. A cross-sectional investigation was conducted on 450 mother-pair newborns from June 2019 to August 2021. Exposure to PM-bound PAHs was estimated at the residential address using spatiotemporal models based on data from 30 monitoring stations across the study area. Umbilical cord blood samples were collected post-delivery for biochemical analysis of renal function markers, including creatinine (Cr), blood urea nitrogen (BUN), and estimated glomerular filtration rate (eGFR). Multivariable regression models were used to assess the relationship between exposure to each PAHs compound and fetal renal function. Moreover, the mixture effects of exposure to PAHs on fetal renal function were assessed using quantile g-computation analysis. Increased concentrations of various PAH compounds at the residential address correlated with raised levels of umbilical BUN and Cr, suggesting potential renal impairment. Notably, exposure to certain PAHs compounds demonstrated statistically negative significant associations with eGFR levels. An increment of one quartile in exposure to PAHs mixture was correlated with a rise of 1.08 mg/dL (95% CI 0.04, 2.11, p = 0.04) and 0.02 mg/dL (95% CI − 0.00, 0.05, p = 0.05) increase in BUN and Cr, respectively. Moreover, a one-quartile increase in PAHs mixture exposure was associated with − 1.09 mL/min/1.73 m2 (95% CI − 2.03, − 0.14, p = 0.02) decrease in eGFR. These findings highlight the potential impact of PAH exposure on fetal renal function and underscore the importance of considering environmental exposures in assessing neonatal renal health outcomes.

Item Type: Article
Uncontrolled Keywords: Fetus, Kidney, Maternal exposure, Neonate, Environmental exposures
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RG Gynecology and obstetrics
R Medicine > RT Nursing
Depositing User: ePrints deposit
Date Deposited: 28 Aug 2024 13:39
Last Modified: 28 Aug 2024 13:39
URI: http://eprints.tiu.edu.iq/id/eprint/1534

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