Role of circular RNAs and gut microbiome in gastrointestinal cancers and therapeutic targets

Tharwat Abdullah, Sara and Rasool Abdullah, Snur and Mahmud Hussen, Bashdar and Mohammed Younis, Yousif and Fatih Rasul, Mohammed and Taheri, Mohammad (2024) Role of circular RNAs and gut microbiome in gastrointestinal cancers and therapeutic targets. Non-coding RNA Research, 9 (1). ISSN 2468-0540

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Abstract

Gastrointestinal cancers are a huge worldwide health concern, which includes a wide variety of digestive tract cancers. Circular RNAs (circRNAs), a kind of non-coding RNA (ncRNAs), are a family of single-stranded, covalently closed RNAs that have become recognized as crucial gene expression regulators, having an impact on several cellular functions in cancer biology. The gut microbiome, which consists of several different bacteria, actively contributes to the regulation of host immunity, inflammation, and metabolism. CircRNAs and the gut microbiome interact significantly to greatly affect the growth of GI cancer. Several studies focus on the complex functions of circRNAs and the gut microbiota in GI cancers, including esophageal cancer, colorectal cancer, gastric cancer, hepatocellular cancer, and pancreatic cancer. It also emphasizes how changed circRNA expression profiles and gut microbiota affect pathways connected to malignancy as well as how circRNAs affect hallmarks of gastrointestinal cancers. Furthermore, circRNAs and gut microbiota have been recommended as biological markers for therapeutic targets as well as diagnostic and prognostic purposes. Targeting circRNAs and the gut microbiota for the treatment of gastrointestinal cancers is also being continued to study. Despite significant initiatives, the connection between circRNAs and the gut microbiota and the emergence of gastrointestinal cancers remains poorly understood. In this study, we will go over the most recent studies to emphasize the key roles of circRNAs and gut microbiota in gastrointestinal cancer progression and therapeutic options. In order to create effective therapies and plan for the future gastrointestinal therapy, it is important to comprehend the functions and mechanisms of circRNAs and the gut microbiota.

Item Type: Article
Uncontrolled Keywords: Circular RNAs Gut microbes Gastrointestinal (GI) cancers Therapeutic target
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Depositing User: ePrints deposit
Date Deposited: 29 Sep 2024 05:54
Last Modified: 29 Sep 2024 05:54
URI: http://eprints.tiu.edu.iq/id/eprint/1633

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