Natural Colorants Induce the Drug Release from Fast Dissolving Tablets

Tariq Bayrakdar, Esra and Visht, Sharad and Kala, Duran and Ameer, Saya and Hamdy, Ahmed and S. Al-Rawi, Sawsan and Bhargava, Samir and Ojha, Abhijeet (2024) Natural Colorants Induce the Drug Release from Fast Dissolving Tablets. Journal of Angiotherapy, 8 (4). ISSN 2207-872X

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Abstract

Background: The use of fast-dissolving tablets (FDTs) presents a promising solution to the challenges faced by certain patient populations, such as children and geriatric patients. FDTs offer rapid disintegration and dissolution in the oral cavity, facilitating drug absorption without the need for water, thus improving dosing accuracy and therapeutic outcomes. This study investigated the impact of hydrophilic and hydrophobic colorants on drug release from FDTs, utilizing Fluorouracil (5-FU) as a model drug and various natural pigments as colorants. Method: The research methodology involved the extraction and characterization of pigments from Opuntia ficus-indica fruits and Nyctanthes arbor-tristis flowers, followed by pre-formulation studies of 5-FU and formulation of FDTs using a direct compression method. Various evaluation parameters were employed to assess the physicochemical properties and performance of the FDTs. Results: The results indicated that the yield of pigments extracted from the fruits and flowers met acceptable standards, with FTIR analysis confirming their chemical composition. Pre-formulation studies of 5-FU revealed its physical and chemical characteristics, ensuring compatibility with excipients. The FDTs exhibited desirable properties such as uniform thickness, drug content uniformity, and acceptable weight variation, hardness, and friability. Moreover, the FDTs demonstrated rapid disintegration, dissolution, and water absorption, along with satisfactory wetting time and in-vitro drug release profiles. Conclusion: FTIR and DSC studies confirmed the absence of drug-excipient interactions, ensuring the stability and integrity of the formulations. Overall, the incorporation of hydrophilic and hydrophobic colorants did not significantly affect the performance of the FDTs, indicating their suitability for use in pharmaceutical formulations.

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