Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets

Mahmud Hussen, Bashdar and Tharwat Abdullah, Sara and Rasool Abdullah, Snur and Mohammed Younis, Yousif and Jamal Hidayat, Hazha and Fatih Rasul, Mohammed and Mohamadtahr, Sayran (2023) Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets. Non-coding RNA Research, 8 (4). ISSN 2468-0540

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Abstract

Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason for death in people with CRC. Recently, it has become clear that exosomes, which are small extracellular vesicles released by non-tumorous and tumorigenic cells, play a critical role as communication mediators among tumor microenvironment (TME). To facilitate communication between the TME and cancer cells, non-coding RNAs (ncRNAs) play a crucial role and are recognized as potent regulators of gene expression and cellular processes, such as metastasis and drug resistance. NcRNAs are now recognized as potent regulators of gene expression and many hallmarks of cancer, including metastasis. Exosomal ncRNAs, like miRNAs, circRNAs, and lncRNAs, have been demonstrated to influence a number of cellular mechanisms that contribute to CRC metastasis. However, the molecular mechanisms that link exosomal ncRNAs with CRC metastasis are not well understood. This review highlights the essential roles that exosomal ncRNAs play in the progression of CRC metastatic disease and explores the therapeutic choices that are open to patients who have CRC metastases. However, exosomal ncRNA treatment strategy development is still in its early phases; consequently, additional investigation is required to improve delivery methods and find novel therapeutic targets as well as confirm the effectiveness and safety of these therapies in preclinical and clinical contexts.

Item Type: Article
Uncontrolled Keywords: Exosomal ncRNAs Metastatic CRC Therapeutic targets
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Depositing User: ePrints deposit
Date Deposited: 23 Sep 2024 13:42
Last Modified: 23 Sep 2024 13:42
URI: http://eprints.tiu.edu.iq/id/eprint/1666

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