Ahamad, Javed and Uthirapathy, Subasini and T. Anwer, Esra and S. Mohammed Ameen, Muath and Samad, Abdul (2021) A Critical Review on Potential Pharmacological Activity and Pharmacokinetic Perspective of Swertiamarin. Research Journal of Phytochemistry, 15 (1). pp. 1-13.
![[img]](https://eprints.tiu.edu.iq/style/images/fileicons/text.png) |
Text (Research Article)
1-13.pdf - Published Version Download (1MB) |
Abstract
Swertiamarin is a secoiridoid glycoside found extensively in Enicostemma littorale and Swertia chirata belonging to the family of Gentianaceae, which has been reported to cure many diseases including diabetes, hypertension, atherosclerosis, arthritis, malaria and abdominal ulcers. The present review aimed to compile up-to-date information on the progress made in the protective role of swertiamarin and its metabolites such as gentianine and erythrocentaurin in diabetes mellitus and related complications to provide a guide for future research on this bioactive molecule. Information on the swertiamarin was collected from major scientific databases (Pubmed, Springer, Google Scholar and Web of Science) for publication in1974-2020. In this review, the role of swertiamarin and its metabolites in the management of diabetes mellitus and related complications was discussed. Swertiamarin and its metabolites reported exhibiting a wide range of biological activities such as antidiabetic, anti-atherosclerotic, anti-inflammatory and antioxidant effects. These activities were mainly due to their effect on various signalling pathways associated with swertiamarin such as PPAR-gene upregulation, P-407-induction, inhibition of HMG-Co A reductase, LDL oxidation, lipid peroxidation markers and stimulation of antioxidant enzymes. Swertiamarin and its metabolites exhibit a wide range of biological activities. This review presents evidence supporting the point of view that swertiamarin should be considered a potential therapeutic agent for the management of diabetes mellitus and related complications, giving rise to novel applications in their prevention and treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Swertiamarin, diabetes mellitus, gentianaceae, Enicostemma littorale, LDL oxidation |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Depositing User: | ePrints deposit |
| Date Deposited: | 23 Sep 2021 07:35 |
| Last Modified: | 23 Sep 2021 07:35 |
| URI: | http://eprints.tiu.edu.iq/id/eprint/736 |
Actions (login required)
 |
View Item |
