GCMS Analysis and Hypolipidemic Activity of Dioscorea bulbifera (L) in High Fat Diet Induced Hypercholesterolemic Rats

Uthirapathy, Subasini and Ahamad, Javed and Porwal, Omji and S. Mohammed Ameen, Muath and T. Anwer, Esra (2021) GCMS Analysis and Hypolipidemic Activity of Dioscorea bulbifera (L) in High Fat Diet Induced Hypercholesterolemic Rats. Research Journal of Phytochemistry, 15 (1). pp. 23-29.

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Background and Objective: Hypercholesterolemia is the leading cause of the development of various diseases that made pharmaceutical companies turn towards herbal products with fewer side effects. Hyperlipidemic and reactive oxygen species in the body are important factors for the development of cardiovascular disease such as hypercholesterolemia. The present study investigated the phytochemical analysis using GCMS and hypolipidemic activity of ethanolic extract of D. bulbifera tubers. Materials and Methods: In the present study, the 70% ethanolic extract of D. bulbifera tubes are attempted to evaluate for the cardio-protective activity and hypolipidemic activity in High fat diet-induced hyperlipidaemia along with the phytochemical evaluation of the same extract by the GC-MS analysis. Results: The results showed that 50 mg kg–1 b.wt., ofD. bulbiferaextract treatment for seven days decreases the level of cholesterol and LDL significantly (p<0.05). Likewise, 30 days of treatment with 50 mg kg–1 b.wt., of D. bulbifera extract exhibits cardioprotective activity in high-fat diet-induced hyperlipidemic rats by increasing HDL cholesterol (p<0.05) and decreasing the total cholesterol, LDL and triglycerides (p<0.05). GC-MS analysis of methanolic fraction from 70% ethanolic extract ofD. bulbifera showed the presence of fatty acids in higher concentrations. Conclusion: The D. bulbifera exhibits hypolipidemic and cardio-protective activity in high-fat diet-induced diseased animals.

Item Type: Article
Uncontrolled Keywords: : Dioscorea bulbifera, GC-MS, high fat diet, lipid profile, phytoconstituents
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Depositing User: ePrints deposit
Date Deposited: 23 Sep 2021 07:35
Last Modified: 23 Sep 2021 07:35
URI: http://eprints.tiu.edu.iq/id/eprint/738

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