Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities

Uthirapathy, Subasini (2021) Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY.

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Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipidemia. In addition, phytochemical evaluation of the same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days of therapy with WS extracts at 1000 mg/kg b.wt. reduced cholesterol by 76%, low-density lipoprotein (LDL) by 71%, and TAG by 12% (P < 0.05). Furthermore, it can significantly reduce cholesterol and LDL levels (P < 0.05). Similarly, the use of 50 mg/kg b.wt. of WS extract showed a cardioprotective effect against isoproterenol-induced cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, and catalase are increased in WS extract (P < 0.05), whereas the release of cardiac indicators in heart tissue is reduced (P < 0.05). Furthermore, a 30-day treatment with WS also reduced triacylglycerol in isoprenaline-induced cardiotoxic rats. GC–MS analysis of the methanol fraction of the Ashwagandha 70% ethanolic extract showed the presence of higher concentrations of fatty acids. In conclusion, WS showed hypolipidemic and cardioprotective activities in diseased animals induced by isoproterenol and Triton WR 1339.

Item Type: Article
Uncontrolled Keywords: Antioxidants, Cardiac markers, Gas chromatography–mass spectrometer, Isoproterenol, Lipid, Triton WR 1339
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Depositing User: ePrints deposit
Date Deposited: 22 Feb 2022 13:50
Last Modified: 22 Feb 2022 13:50
URI: http://eprints.tiu.edu.iq/id/eprint/827

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