Transgenic Black Mice Induction model for Human Leucoderma

Uthirapathy, Subasini (2021) Transgenic Black Mice Induction model for Human Leucoderma. NVEO, 8 (5).

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There has been little research evaluating the efficacy and safety of 4 hydroxyl anisole + TRA (4 HA + TRA) in an animal model for Leucoderma.To test the first model of leucoderma to induce epidermal depigmentation, an attempt has been made to achieve an animal model using transgenic mice 4HA+ TRA applications of 3 and 5 % produced depigmentation, but depigmentation was found to be better in 5 %. The inducted skin in the transgenic mice was fixed in 10 % neutral formalin and processed by the routine histological technique using F/M methods for the presence/absence of melanin. Good compliance, exposure, and rising cumulative dose were all linked to a better response to therapy, which was statistically significant (P < 0.01). In addition, there were just minor side effects. During follow-up, only half of the animals had depigmentation at the sites. Our research shows that 4HA combined with TRA is an effective model for Leucoderma, with good depigmentation of the epidermis occurs within 3-4 weeks in a white patchy pattern similar to patients with vitiligo.

Item Type: Article
Uncontrolled Keywords: Ito S. Jimbow K ( 1983). Quantitative analysis of eumelanin and pheomelanin in hair and melanosomes. J Invest Dermatol 80:268-272.21.Tietze F1980. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal Biochem 27: 207-212. 22.Prota G (1980). Recent advances in the chemistry of melanogenesis in mammals, J Invest Dermatol 75:122-127. 23.ProtaG (1972). Structure and biogenesis of pheomelanins, pigmentation: Itsgenesis and Biologic control. Edited by Riley. New York, Appleton-century-crofts 615-630.24.Xina Nair, Prakash Parab, Leigh suhr, and Kenneth M (1995). Combination of 4-Hydroxyanisole and All-Trans Retinoic Acid produced synergistic skin depigmentation in swine by the society for Investigative Dermatology, Inc 145-149.
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Depositing User: ePrints deposit
Date Deposited: 15 Mar 2022 10:21
Last Modified: 15 Mar 2022 10:21

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