4,4’-bis-[4-(substituted-phenyl)-1-azetidinyl-2-one]-biphenyl Via an Improved Procedure Using Zn-Cu Couple in Sonic Reformatsky Reaction

H.S. Hussain, Faiq and H.R. Al-Chawshili, Lana (2019) 4,4’-bis-[4-(substituted-phenyl)-1-azetidinyl-2-one]-biphenyl Via an Improved Procedure Using Zn-Cu Couple in Sonic Reformatsky Reaction. Eurasian Journal of Science and Engineering, 4 (4). pp. 148-155. ISSN 24145629

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Abstract

Considerable interest has been focused on azetidinone (β-lactam) compounds for their broad spectrum antimicrobial activity. Therefore, a new series of bis-azetidinone compounds (5a-l) have been synthesized via the reaction of new Schiff bases (3a-l) with ethylbromoacetate and Zn-Cu couple in THF under nitrogen pressure with ultrasonic agitation. The structure of isolated products was confirmed spectroscopically. On the other hand, the prepared compounds were tested in vitro for their antimicrobial activity against Staphylococcus aurous and Escherichia coli.

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