Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones5-Carboxamide) by Using Ultrasonic Irradiation

H.S. Hussain, Faiq and O. Abdulla, Havall (2018) Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones5-Carboxamide) by Using Ultrasonic Irradiation. Eurasian Journal of Science and Engineering, 3 (3). pp. 132-144. ISSN 24145629

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Abstract

This investigation involves synthesis of two new series of bis-dihydropyrimidinone-5- carboxamides (4 a-k) and (5 a-k) from reaction of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride and its derivatives (3 a, b) with different diamines using ultrasonic irradiation. Compounds (3a, b) were synthesized from chlorination of 6-methyl-2-oxo-4- phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid and its derivatives (2a,b) which were prepared from hydrolysis of ethyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimi-dine-5-carbo-xylate and its derivatives (1a, b) which was synthesized by one-pot Biginelli condensation. The synthesized products were characterized by physico-chemical methods such as elemental analysis (CHNS-O), FT-IR, 1H-NMR and 13C-NMR. The prepared compounds were showed biological activity against two types of bacterial Escherichia coli Gram-negative bacteria (G -ve) and Staphylococcus aureas Gram-positive bacteria (G +ve).

Item Type: Article
Uncontrolled Keywords: Dihydropyrimidinone, Biginelli Condensation, Ultrasonic, Hydrolysis, Catalytic Reaction
Subjects: Q Science > QD Chemistry
Divisions: Eurasian Journal of Science and Engineering > VOL 3, NO 3 (2018)
Depositing User: ePrints deposit
Date Deposited: 14 Oct 2020 18:41
Last Modified: 23 Feb 2021 07:48
URI: http://eprints.tiu.edu.iq/id/eprint/244

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