Toxicity profiles of the hydroalocholic seed extract of Psoralea Corylifolia L Fabaceae in Wistar rats

Uthirapathy, Subasini and Ahamad, Javed (2022) Toxicity profiles of the hydroalocholic seed extract of Psoralea Corylifolia L Fabaceae in Wistar rats. Academic Journal of Health Sciencies Medicina balear.

Text (Research Article) AJHS_Medicina_Balear_2022v37n3p120.pdf - Published Version Download (2MB)

Abstract

Introduction: Ayurveda is well known system of medicine and practiced in Indian subcontinent since about 5000 years. Ayurveda offers holistic life style caring for the individual’s mind and spirit as well as their body. Psoralea corylifolia Linn. (Fabaceae) is well known traditional plant used in Ayurveda and Chinese system of medicines and known for its beneficial actions in skin diseases such as psoriasis, alopecia, leprosy, leucoderma, and vitiligo etc. Objective: The aim of present study to determine toxicity of hydroalcoholic extract of P. corylifolia in acute and sub-chronic toxicity assay models. Methods: The albino mice were used in cute toxicity study for dose ranging from 10 to 1000 mg/kg, b.w.; and in sub-chronic toxicity assay, albino wistar rat used for dose ranging from 100 to 500 mg/kg, b.w. Daily body weight, food intake and different biochemical and haematological parameters were measured. Macroscopic observation of the vital organ of the test groups when compared to the control group. Results: The results of toxicity study showed that there are no toxic symptoms produced in acute as well as in sub-chronic toxicity studies upto 1000 mg/kg, b.w. when tested in albino mice and rats orally. The overall behaviour of the animals was more active and healthy during the treatment period. It was found that there was no remarkable difference indicating the non-toxic property of the seed extract on acute toxicity and sub-acute repeated administration causes mild adverse effects. Conclusion: The current study provides scientific data on safety of P. corylifolia.

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